Obično prijateljstvo sa psom lutalicom i neobičan medicinski eksperiment izvrnuće život profesora Preobraženskog. Presadivši psu žlezde preminulog čoveka stvorio je vlastitog frankenštajnovskog monstruma. Mora se suočiti s mračnom činjenicom: nije najgori čovek sa psećim srcem već onaj sa srcem čoveka.
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